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The influence of protein binding on disopyramide clearance

✍ Scribed by S. M. Bryson; J. R. Lawrence; W. H. Steele; B. C. Campbell; H. L. Elliott; D. J. Sumner

Publisher
Springer
Year
1982
Tongue
English
Weight
387 KB
Volume
23
Category
Article
ISSN
0031-6970

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## Abstract Following bolus intravenous injection of disopyramide in eight normal volunteers the renal clearance of the drug appeared to fall with time. In the first two hours after injection renal clearance had a mean value of 89Β·0 ml min^βˆ’1^ and fell to 29Β·4 ml min^βˆ’1^ between 48 and 72 h. In a

Influence of concentration-dependent pro
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## Abstract Concentrations of disopyramide (D) and mono‐N‐dealkyldisopyramide (MND) were measured in serum and urine following administration of 100, 150, 200, and 300 mg D to four volunteers. The free fraction of D in serum was drug concentration‐dependent in all four subjects following the admini