The Influence of Paternal Age on Down Syndrome
β Scribed by FISCH, HARRY; HYUN, GRACE; GOLDEN, ROBERT; HENSLE, TERRY W.; OLSSON, CARL A.; LIBERSON, GARY L.
- Book ID
- 121955247
- Publisher
- Lippincott Williams and Wilkins
- Year
- 2003
- Tongue
- English
- Weight
- 291 KB
- Volume
- 169
- Category
- Article
- ISSN
- 0022-5347
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π SIMILAR VOLUMES
## SUMMARY Recent cytogenetic evidence has shown that trisomy 21 can arise, perhaps even in substantial proportion, from paternal nondisjunction. The statistical association between Down syndrome incidence and maternal age, paternal age and birth order has been studied in a sample of over 4000 case
The recent discovery that the extra chromosome in about 30% of cases of 47, trisomy 21 is of paternal origin has revived interest in the possibility of paternal age as a risk factor for a Down syndrome birth, independent of maternal age. Parental age distribution for 611 Down's syndrome 47, +21 case
Paternal age distribution for 1279 cases of Down's syndrome born in 1952--1968 was compared with the corresponding distribution for the general population, corrected for the maternal age as well as for the year of birth of the patients. Although there was no difference in the mean paternal age, the