## Abstract Parathyroid hormoneβrelated peptide (PTHrP) and parathyroid hormone (PTH) have similar biological effects in vitro that are mediated through the PTH receptor. PTH receptors have been demonstrated in the zone of provisional calcification and the hypertrophic zone of the cartilaginous gro
The influence of parathyroid hormone on the aggregation of isolated chondrocytes
β Scribed by P. J. Gaillard; S. Moskalewski; M. J. Verhoog; A. M. Wassenaar
- Book ID
- 105449685
- Publisher
- Springer
- Year
- 1968
- Tongue
- English
- Weight
- 368 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1432-0827
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Parathyroid hormone (PTH) binds specifically to the hypertrophic region of growth plate cartilage [16]. This specific binding suggests a role for this hormone in chondrocyte maturation. Enzymatically isolated chick articular and growth plate chondrocytes grown in monolayer culture were used to assay
## Abstract In the growth plate chondrocyte, parathyroid hormone (PTH) stimulates phosphoinositol 4, 5 bisphosphate (PIP~2~) degradation, which results in the rapid production of inositol (1,4,5) triphosphate (IP~3~). IP~3~ induced the release of calcium from an intracellular store, which caused a