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The influence of maternal nicotine exposure on neonatal lung alveolar epithelial status: an electron microscope study.

✍ Scribed by G.S. Maritz; L. Scott; R-A. Thomas

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
465 KB
Volume
17
Category
Article
ISSN
1065-6995

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✦ Synopsis

Abstract

The aim of the present study was to investigate the effect of maternal nicotine exposure (1 mg nicotine/kg body mass/day) on neonatal lung alveolar epithelial cells. Rats (Wistar descendants) were used. The data illustrate that maternal nicotine exposure during pregnancy and lactation resulted in alveolar fenestrations, blebbing and rupturing of the blood‐air barrier. The type I pneumocyte appears to be more sensitive to the effect of nicotine than the type II pneumocytes.

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✍ G.S. Maritz 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 284 KB

## Abstract The aim of the present study was to establish whether ascorbic acid supplementation (1 mg/kg/body mass/day) during pregnancy and lactation will prevent the effect of maternal nicotine exposure (1 mg/kg body weight/day) on neonatal lung carbohydrate, DNA and protein metabolism. The data