The influence of lymph node metastasis and ulceration of primary melanoma on germinal centers within draining lymph nodes: A histomorphometric study

✍ Scribed by F. Weidner; S. Schroll; A. Schönberger

• Publisher: Springer-Verlag
• Year: 1981
• Tongue: English
• Weight: 751 KB
• Volume: 272
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00510408

✦ Synopsis

Microscopic counts and histoelectronic measurement of germinal centers in regional lymph nodes of melanoma patients showed a significant progressive increase in average number, as well as area, of germinal centers with occurrence of (adjacent) metastasis and presence of primary-tumor ulceration. The findings confirm in a quantitative manner the stage-dependent effect of progressive liberation of tumor antigen [10] on lymph node centers of humoral immune response.