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The influence of lymph node metastasis and ulceration of primary melanoma on germinal centers within draining lymph nodes: A histomorphometric study

✍ Scribed by F. Weidner; S. Schroll; A. Schönberger


Publisher
Springer-Verlag
Year
1981
Tongue
English
Weight
751 KB
Volume
272
Category
Article
ISSN
0340-3696

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✦ Synopsis


Microscopic counts and histoelectronic measurement of germinal centers in regional lymph nodes of melanoma patients showed a significant progressive increase in average number, as well as area, of germinal centers with occurrence of (adjacent) metastasis and presence of primary-tumor ulceration. The findings confirm in a quantitative manner the stage-dependent effect of progressive liberation of tumor antigen [10] on lymph node centers of humoral immune response.


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