𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The influence of local cooling on neuromuscular transmission in the myasthenic syndrome of eaton and lambert

✍ Scribed by K. Ricker; G. Hertel; S. Stodieck

Publisher
Springer
Year
1977
Tongue
English
Weight
709 KB
Volume
217
Category
Article
ISSN
0340-5354

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of local cooling was studied in two patients with the Eaton-Lambert syndrome. We stimulated the ulnar nerve and registered the compound muscle action potential, the twitch force, and the maximum tetanic force. A distinct improvement of neuromuscular transmission occurred after cooling. The amplitude of the muscle action potential and the twitch force were larger and the time of the postactivation facilitation was longer. This effect of cooling is similar to the effect of guanidine on neuromuscular transmission. The release of acetylcholine at the nerve terminal is probably enhanced by cooling.

πŸ“œ SIMILAR VOLUMES

Effect of 3,4-diaminopyridine on the tim
Effect of 3,4-diaminopyridine on the time course of decay of compound muscle action potential augmentation in the Lambert–Eaton myasthenic syndrome
✍ Paul Maddison; John Newsom-Davis; Kerry R. Mills πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 123 KB πŸ‘ 2 views

Diaminopyridine (3,4-DAP) is known to be beneficial in the symptomatic treatment of the Lambert-Eaton myasthenic syndrome (LEMS). The effects of 3,4-DAP on the decay of postexercise augmentation were observed in 6 patients with LEMS. After 10 s maximal voluntary contraction, the amplitude of the co