The influence of limited presynaptic growth and synapse removal on adaptive synaptogenesis
โ Scribed by Dawn M. Adelsberger-Mangan; William B Levy
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 798 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0340-1200
No coin nor oath required. For personal study only.
โฆ Synopsis
This report continues our research into the effectiveness of adaptive synaptogenesis in constructing feed-forward networks which perform good transformations on their inputs. Good transformations are characterized by the maintenance of input information and the removal of statistical dependence. Adaptive synaptogenesis stochastically builds and sculpts a synaptic connectivity in initially unconnected networks using two mechanisms. The first, synaptogenesis, creates new, excitatory, feed-forward connections. The second, associative modification, adjusts the strength of existing synapses. Our previous implementations of synaptogenesis only incorporated a postsynaptic regulatory process, receptivity to new innervation (Adelsberger-Mangan and Levy 1993a, b). In the present study, a presynaptic regulatory process, presynaptic avidity, which regulates the tendency of a presynaptic neuron to participate in a new synaptic connection as a function of its total synaptic weight, is incorporated into the synaptogenesis process. In addition, we investigate a third mechanism, selective synapse removal. This process removes synapses between neurons whose firing is poorly correlated. Networks that are constructed with the presynaptic regulatory process maintain more information and remove more statistical dependence than networks constructed with postsynaptic receptivity and associative modification alone. Selective synapse removal also improves network performance, but only when implemented in conjunction with the presynaptic regulatory process.
๐ SIMILAR VOLUMES
## Abstract The culture levels of glucose and CO~2~ have been reported to independently have important influences on mammalian cell processes. In this work the combined effects of glucose limitation and CO~2~ partial pressure (__p__CO~2~) on monoclonal antibody (IgG) producing Chinese Hamster Ovary