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The influence of inhaled formaldehyde on rat lung cytochrome P450

✍ Scribed by Cham E. Dallas; Pam Badeaux; Jeff C. Theiss; Edward J. Fairchild

Book ID
117097663
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
652 KB
Volume
49
Category
Article
ISSN
0013-9351

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m-Xylene inhalation destroys cytochrome
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Rats were exposed to 0, 75, 150 or 300 ppm (1 ppm = 1 cm3/m3 = 4.35 mg/m3) m-xylene for 24 h and then killed. In the lungs, the cytochrome P-450 decreased to 45, 13 and 20% of the control value with the increasing exposure intensity and the activity of 7-ethoxycoumarin O-deethylase to 70, 27 and 14%