The influence of infusion rate on the pharmacokinetics and haemodynamic effects of nisoldipine in man.
โ Scribed by J. van Harten; P. van Brummelen; RR Zeegers; M. Danhof; DD Breimer
- Book ID
- 117944611
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 968 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0306-5251
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๐ SIMILAR VOLUMES
We have studied the pharmacokinetics and haemodynamic effects of nicorandil after a 12-h infusion. Nicorandil is a mixed vasodilator combining the actions of a nitrate and a potassium channel opener. Nicorandil was infused for 12 h in 21 healthy volunteers at rates of 0.05, 0.10, and 0.20 microgram.
Six normal volunteers were studied on four separate occasions. On each occasion they received two concomitant infusions which were either placebo/placebo, placebo/tyramine, angiotensin II/placebo or angiotensin II/tyramine. Angiotensin II infusion was given at a constant rate of 2ng/kg/min whereas t