The influence of HLA–DRB1 alleles and rheumatoid factor on disease outcome in an inception cohort of patients with early inflammatory arthritis
✍ Scribed by Beverley Harrison; Wendy Thomson; Deborah Symmons; Bill Ollier; Nicola Wiles; Tony Payton; Elizabeth Barrett; Alan Silman
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 147 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0004-3591
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📜 SIMILAR VOLUMES
Objective. To investigate whether interactions between tumor necrosis factor (TNF) microsatellite polymorphisms and the HLA-DRB1 shared epitope (SE) are associated with disease severity in rheumatoid arthritis (RA), and to determine if such associations are the same in male and female patients. Met
## Abstract ## Objective It has been found that women with rheumatoid arthritis (RA) have a poorer prognosis than men. However, the impact of age at symptom onset is unclear. We investigated the relationship between these factors and functional disability in patients with recent‐onset inflammatory