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The Influence of HLA-DR4 (0401) on the Immune Response to Type II Collagen and the Development of Collagen Induced Arthritis in Mice

✍ Scribed by Dequn Wang; Jonathan A Hill; Ewa Cairns; David A Bell

Book ID: 115621889
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 151 KB
Volume: 18
Category: Article
ISSN: 0896-8411
DOI: 10.1006/jaut.2001.0569

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## Abstract ## Objective To establish a new animal model in DRB1\*0401 (DR4)–transgenic mice in which T cell tolerance to self type II collagen (CII) can be broken and allow for the development of autoimmune arthritis, to investigate the role of posttranslational modifications of the CII^259–273^