The influence of graft size on the induction of immunity versus tolerance to H-Y inH-2kstrains of mice

✍ Scribed by R. B. Ashman

• Book ID: 104770818
• Publisher: Springer-Verlag
• Year: 1985
• Tongue: English
• Weight: 405 KB
• Volume: 22
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00430306

✦ Synopsis

Unprimed female CBA mice do not reject large (10 mm 2) syngeneic male skin grafts. However, a high proportion do reject small (4 mm 2) grafts. Nevertheless, rejection does not invariably result in an anamnestic response. In some cases, the immunity induced by the rejection of a small graft was overcome, and tolerance was induced by a subsequent challenge with a large graft. This suggests that the transplantation response to minor antigens is subject to active regulation, and screening of other H-2 k strains indicates that the nature of the response (i. e., immunity or tolerance) is determined by a gene or genes mapping outside the major histocompatibility complex.