The influence of ethanol on cyclophosphamide pharmacokinetics and metabolism in tumor-bearing rats
β Scribed by E.A. de Bruijn; A.T. van Oosterom; U.R. Tjaden
- Book ID
- 118385428
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 449 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0163-7258
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Adult rats were given 105 or 106 Yoshida ascites sarcoma (YAS) cells IP and were treated with cyclophosphamide (CY) given IP in single doses of 20 mg/kg or 100 mg/kg, 2 or 5 days after YAS inoculation. Both the curative effect of CY and subsequent resistance to tumor challenge in rats that survived
## Abstract A brain tumor, originally induced by weekly IV injections of Nβnitroβsomethylurea in CD Fisher rats and subsequently carried in serial subcultures, was inoculated SC in the flank of CD Fisher rats. The synthesis and concentrations of the polyamines were studied at various times after th