The influence of enrichment with cholesterol on the phagocytic activity of rat macro-phages

✍ Scribed by Mario U. Dianzani; Mario V. Torrielli; Rosa A. Canuto; Renato Garcea; Francesco Feo

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 441 KB
• Volume: 118
• Category: Article
• ISSN: 0022-3417
• DOI: 10.1002/path.1711180402

✦ Synopsis

Prolonged treatment of rats with a cholesterol-rich diet induced hypercholesterolaemia and increased free cholesterol content of peritoneal macrophages. A 2-2 times increase in plasma membrane cholesterol was demonstrated in cholesterol-enriched macrophages. These cells showed a significant inhibition of phagocytosis. The inhibition was 37-0% and 81-7% for latex particles or lipid droplets, respectively.