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The influence of dissolved oxygen tension on the synthesis of the antibiotic difficidin by bacillus subtilis

โœ Scribed by M. Suphantharika; A. P. Ison; M. D. Lilly; B. C. Buckland

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
491 KB
Volume
44
Category
Article
ISSN
0006-3592

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โœฆ Synopsis

Abstract

The antibiotic, difficidin, and its hydroxylated derivative oxydifficidin, were synthesized by cultures of Bacillus subtilis grown on a complex medium. Maximum titers of about 200 and 130 mg/L, respectively, were obtained. In fermentations where the dissolved oxygen tension (DOT) was controlled, the maximum specific growth rate was only reduced below 5% air saturation. DOT had little effect on the volumetric rateof synthesis of oxydifficidin but greatly influenced the rate for difficidin, which was reduced at DOT values below 40% air saturation. ยฉ 1994 John Wiley & Sons, Inc.

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