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The influence of corticosteroids on the release of novel biomarkers in human endotoxemia

✍ Scribed by Martijn D. de Kruif; Lucienne C. Lemaire; Ida A. Giebelen; Joachim Struck; Nils G. Morgenthaler; Jana Papassotiriou; Peter J. Elliott; Tom van der Poll

Publisher
Springer
Year
2007
Tongue
English
Weight
116 KB
Volume
34
Category
Article
ISSN
1432-1238

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Endotoxemia decreases the dose requirement for anesthetics but no data are available for propofol. A rat model was used in which the influence of endotoxin administration on the pharmacokinetics and pharmacodynamics of propofol was investigated. Chronically instrumented rats were randomly allocated