✦ LIBER ✦

The influence of chemotherapy on the distribution of57Co-bleomycin in chemically induced squamous cell carcinoma of mouse skin

✍ Scribed by T. Pertynski; G. Reznik; P. Mariß; M. B. Ketkar; H. Haindl; G. Dieffenbach

Publisher: Springer
Year: 1979
Tongue: English
Weight: 379 KB
Volume: 4
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00257571

No coin nor oath required. For personal study only.

✦ Synopsis

Organ distribution and tumor uptake of 57Co-bleomycin (BLM) were examined in NMRI mice without tumor and with chemically (DMBA-) induced squamous cell carcinoma. In these tumors high accumulation of 57Co-BLM was recorded shortly after injection of 57Co-BLM and low uptake 24--48 h after application. Two groups of tumor-bearing mice received unlabeled bleomycin as a cytostatic in two different doses. Uptake of 57Co-bleomycin was reduced. The study suggests that in patients currently or previously under chemotherapy, 57Co-bleomycin tumor scintigraphy may lead to false negative results.

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