The influence of cardiac output distribution on the tissue/plasma drug concentration ratio
โ Scribed by Pietro Fagiolino
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 432 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0378-7966
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๐ SIMILAR VOLUMES
One of the drug specific parameters needed in physiologically based pharmacokinetic (PBPK) models is the tissue to plasma drug concentration ratios (K(p) values). The aim of this study was to develop an empirical method for predicting K(p) values using a preclinically determined in vivo volume of di
Calcium channel blockers are used in the treatment of angina pectoris, cardiac arrhythmia, and hypertension. Sporadic reports of hypotensive reactions to verapamil have indicated that these reactions are not reversed readily by catecholamine administration. This study was conducted to test the hypot