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The influence of antihistamines on human performance

โœ Scribed by A. W. K. Gaillard; A. Gruisen; R. Jong

Publisher
Springer
Year
1988
Tongue
English
Weight
579 KB
Volume
35
Category
Article
ISSN
0031-6970

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Structure-activity relationship studies were conducted to reduce CYP2D6-mediated metabolism in a series of indene H 1 -antihistamines. Reductions in pK a via incorporation of a b-fluoro substituent or a heteroaryl moiety were shown to reduce contributions to metabolism through this pathway. Several