𝔖 Scriptorium
✦   LIBER   ✦
📁

The Inflammasomes

✍ Scribed by Virginie Pétrilli, Fabio Martinon (auth.), Isabelle Couillin, Virginie Pétrilli, Fabio Martinon (eds.)

Publisher
Springer Basel
Year
2011
Tongue
English
Leaves
239
Series
Progress in Inflammation Research
Edition
1
Category
Library
⬇  Acquire This Volume

No coin nor oath required. For personal study only.

✦ Synopsis

The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.

✦ Table of Contents

Front Matter....Pages i-xiii
Molecular Definition of Inflammasomes....Pages 1-16
Pyroptosis: A Caspase-1-Dependent Programmed Cell Death and a Barrier to Infection....Pages 17-36
Activation of the Inflammasome by Bacterial Pathogens....Pages 37-50
The Role of Inflammasomes in Viral Infection....Pages 51-64
Inflammasome Activation in Response to Eukaryotic Pathogens....Pages 65-83
Inflammasome Activation by Pathogenic Crystals and Particles....Pages 85-99
Inflammasome Activation by Danger Signals....Pages 101-121
Toll-Like Receptors and Inflammasomes....Pages 123-132
Inflammasome in the Skin....Pages 133-149
Cancer, Inflammasomes, and Adjuvanticity....Pages 151-163
Inflammasome and Lung Pathologies....Pages 165-182
Mechanisms of NLRP3 Inflammasome Activation in CAPS Patients....Pages 183-195
Activation and Regulation of the NLRP3 Inflammasome....Pages 197-208
Treatment of Inflammasome-Related Disorders....Pages 209-220
Back Matter....Pages 221-223

✦ Subjects

Immunology; Infectious Diseases; Cell Biology; Cytokines and Growth Factors; Enzymology

📜 SIMILAR VOLUMES

The Inflammasome: Methods and Protocols
📁 The Inflammasome: Methods and Protocols
✍ Mareike Schnaars, Hannes Beckert, Annett Halle (auth.), Christine M. De Nardo, E 📂 Library 📅 2013 🏛 Humana Press 🌐 English

<p><p> Inflammasomes have a seemingly simple architecture. A sensor molecule of the NLR or PYHIN protein family recruits the common adapter molecule apoptosis-associated speck-like protein containing a CARD (ASC). Even so, inflammasome activation is highly regulated at multiple steps and precise det

The Inflammasome: Methods and Protocols
📁 The Inflammasome: Methods and Protocols
✍ Christine M. De Nardo, Eicke Latz 📂 Library 📅 2013 🏛 Humana Press 🌐 English

This Methods in Molecular Biology book offers methods for studying inflammasome function, including generation of inflammasome stimuli, monitoring of caspase-1 activity and processing, activation of IL-1β cytokines, plus lab protocols, material lists and tips.

The Inflammasome: Methods and Protocols
📁 The Inflammasome: Methods and Protocols
✍ Christine M. De Nardo, Eicke Latz 📂 Library 📅 2013 🏛 Humana Press 🌐 English

This Methods in Molecular Biology book offers methods for studying inflammasome function, including generation of inflammasome stimuli, monitoring of caspase-1 activity and processing, activation of IL-1β cytokines, plus lab protocols, material lists and tips.

Inflammasomes: Clinical and Therapeutic
📁 Inflammasomes: Clinical and Therapeutic Implications
✍ Mario D. Cordero, Elísabet Alcocer-Gómez 📂 Library 📅 2018 🏛 Springer International Publishing 🌐 English

<p><p>The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome h

Inflammasomes: Clinical and Therapeutic
📁 Inflammasomes: Clinical and Therapeutic Implications
✍ Mario D. Cordero; Elísabet Alcocer-Gómez 📂 Library 📅 2018 🏛 Springer 🌐 English

The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome has bee

Inflammasome Signaling and Bacterial Inf
📁 Inflammasome Signaling and Bacterial Infections
✍ Steffen Backert (ed.) 📂 Library 📅 2016 🏛 Springer 🌐 English

<p>This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease patho