We have analyzed the role of cognate interaction with helper T cells (Th) in support of resting B cell differentiation to plaque formation. Co-culture of histoincompatible resting B cells and resting Th cells resulted in the induction of plaque-forming cells when dimeric but not monomeric fragments
The induction of resting B cell differentiation does not require T cell contact
β Scribed by Michael Julius; Lori Haughn
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 808 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0014-2980
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It has previously been reported (Hiinig, T. et al., Eur. J. Zmmunol. 1983. 13: 1) that highly purified peripheral T cells do not respond to concanavalin A (Con A) even in the presence of Con A-induced spleen cell supernatant as a source of interleukin 2 (IL 2). In the present report, the hypothesis