Kinetics of the uptake of [3H]paroxetine
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Paul Cumming; Albert Gjedde
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Article
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1993
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John Wiley and Sons
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English
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Paroxetine, an antidepressant with a high affinity for serotonin (5-HT) re-uptake sites, is a potential tracer of these sites. We determined the kinetic properties of ["Hlparoxetine in rat brain in vivo. Relative to [l4C1iodo-antipyrine, the brain uptake index (BUI) of r3H1paroxetine was 60-70%. The