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The in Vivo Rate of Somatic Adenomatous Polyposis Coli Mutation

✍ Scribed by Chris Hornsby; Karen M. Page; Ian Tomlinson


Book ID
117970747
Publisher
American Society for Investigative Pathology
Year
2008
Tongue
English
Weight
400 KB
Volume
172
Category
Article
ISSN
0002-9440

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## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with

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## Abstract Patients with familial adenomatous polyposis coli (FAP) carry heterozygous mutations of the __APC__ gene. At a young age, these patients develop multiple colorectal adenomas that consistently display a second somatic mutation in the remaining __APC__ wild‐type allele. Inactivation of AP