Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene p
The in Vivo Rate of Somatic Adenomatous Polyposis Coli Mutation
β Scribed by Chris Hornsby; Karen M. Page; Ian Tomlinson
- Book ID
- 117970747
- Publisher
- American Society for Investigative Pathology
- Year
- 2008
- Tongue
- English
- Weight
- 400 KB
- Volume
- 172
- Category
- Article
- ISSN
- 0002-9440
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π SIMILAR VOLUMES
## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm
## Abstract Patients with familial adenomatous polyposis coli (FAP) carry heterozygous mutations of the __APC__ gene. At a young age, these patients develop multiple colorectal adenomas that consistently display a second somatic mutation in the remaining __APC__ wildβtype allele. Inactivation of AP