The in vivo expression of the globin genes of theβcistron in γ-,δ-, andδβ-thalassemia heterozygotes
✍ Scribed by A. J. Dimovski; A. D. Adekile; T. H. J. Huisman
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 333 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1420-682X
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Based on precise evaluation of hematological findings and clinical manifestations, the relationship between genotype and clinical phenotype was studied in 475 Greek patients with /? and d/~ thalassemias. Almost all known genotypes are included in this series, but the most frequent was homozygous pth
An investigation of the correlation between the y->p-globin switch and DNA methylation was carried out. The restriction patterns obtained with methylation-sensitive and -insensitive enzymes indicated hypomethylation in the promoter region of the r-globin genes in fetal liver DNA but high methylation