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The in-vivo effect of sodium-potassium citrate on the crystal growth rate of calcium oxalate and other parameters in human urine

✍ Scribed by Achilles, W. ;Schulze, D. ;Schalk, Chr. ;Rodeck, G.

Publisher: Springer
Year: 1990
Tongue: English
Weight: 575 KB
Volume: 18
Category: Article
ISSN: 0300-5623
DOI: 10.1007/bf00294572

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✦ Synopsis

In this study, an efficient microtechnique (gel crystallization method) was used to investigate the in-vivo effect of sodium-potassium citrate on the crystal growth rate of calcium oxalate (Vcr) in human urine samples of 6 healthy volunteers. With a daily dose of 3 X 11 mmol of alkali citrate, Vcr decreased by 70%. This could have been due to the decrease of calcium excretion, which caused 50-60% of the total change, and to the increase of citrate and pH, each contributing about 20-25% to the decline of Vcr. The findings explain the clinical advantages of alkali citrates in the prevention of recurrent calcium oxalate stone formation.

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