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The in vivo but not the in vitro am3 revertant frequencies increase linearly with increased ethylnitrosourea doses in spleen of mice transgenic for phiX174 am3, cs70 using the single burst assay

✍ Scribed by Robert P Weaver; Heinrich V Malling

Book ID: 117767040
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 138 KB
Volume: 534
Category: Article
ISSN: 1383-5718
DOI: 10.1016/s1383-5718(02)00242-5

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## Abstract In mutation assays using transgenic mice, with recoverable vectors such as ΦX174 __am3, cs70,__ mutations originate from two sources: (1) in vivo mutations, that is, mutations that were fixed in the mouse, or (2) ex vivo mutations, that is, mutations that were fixed during recovery or p