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The in vitro effects and metabolism-mediated cytotoxicity of phorone, a glutathione-depleting agent

โœ Scribed by Reader, S.J.; Clothier, R.H.; Yu, J.; Balls, M.

Book ID
123230083
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
335 KB
Volume
4
Category
Article
ISSN
0887-2333

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Although the depletion of hepatic glutathione in male rats following treatment with phorone (diisopropylidene acetone) did not affect the xenobiotic-metabolizing microsomal enzyme system, the metabolic elimination of vinylidene chloride (VDC) from the atmosphere of a closed exposure system was inhib