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The in vitro effect of substance P on the GnRH-induced LH release depends on the steroidal environment and is reverted by a NK1 receptor antagonist (RP 67580) in the cycling female rat

✍ Scribed by P Duval; V Lenoir; B Kerdelhué


Book ID
114118374
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
447 KB
Volume
32
Category
Article
ISSN
0143-4179

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Utilizing a human NK 1 receptor antagonist (RPR 100893), the present in vivo study was designed to test the hypothesis that endogenous substance P (SP) modulates the action of 17␤-estradiol in inducing luteinizing hormone (LH) and follicle stimulating hormone (FSH) surges in ovariectomized cynomolgu