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The in vitro and in vivo biotransformation of N-deacetyl-N-formylcolchicine

✍ Scribed by V. Lukić; A. Husek; O. GaŠić; D. Walterova; V. Šimanek


Book ID
113006764
Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
455 KB
Volume
17
Category
Article
ISSN
0378-7966

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✍ Leo W. Brown; Arlington A. Forist 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 English ⚖ 351 KB

The kinetics of hydrolysis of the carbamoyl group in salicylanilide N-methylcarbamate (I) and 4-biphenylyl N-methylcarbamate (11) showed that the reaction was first order with respect to both hydroxide ion and carbamate. At 37", the hydroxideion-catalyzed hydrolysis of 1 to yield salicylanilide (111