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The in vitro 5-lipoxygenase and cyclo-oxygenase inhibitor L-652,343 does not inhibit 5-lipoxygenase in vivo in human skin.

✍ Scribed by RM Barr; AK Black; PM Dowd; O Koro; K Mistry; JL Isaacs; MW Greaves


Book ID
119833480
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
558 KB
Volume
25
Category
Article
ISSN
0306-5251

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The purpose of the present study was to determine the effect of the n-6 fatty acid, dihomogammalinolenic acid (DGLA, 20 : 3, n-6) on arachidonic acid (AA) (C20:4) metabolism by human peripheral mononuclear leukocytes (HPML). After incubation of HPML with A23187 (5 ~tM) and DGLA, the cyclooxygenase (