The importance of vitamin C for hydroxylation of vitamin D3 to 1,25(OH)2D3 in man
โ Scribed by F. P. Cantatore; M. C. Loperfido; D. M. Magli; L. Mancini; M. Carrozzo
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 438 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0770-3198
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๐ SIMILAR VOLUMES
1,25-dihydroxy-vitamin D(3) (1,25(OH)(2)D(3)), the hormonally active form of vitamin D(3), acts through two different mechanisms. In addition to regulating gene expression via the specific intracellular vitamin D receptor (VDR), 1,25(OH)(2)D(3) induces rapid, non-transcriptional responses involving
1alpha,25(OH)(2)D(3) regulates rat growth plate chondrocytes via nuclear vitamin D receptor (1,25-nVDR) and membrane VDR (1,25-mVDR) mechanisms. To assess the relationship between the receptors, we examined the membrane response to 1alpha,25(OH)(2)D(3) in costochondral cartilage cells from wild type