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The importance of thyroid hormone transporters for brain development and function

✍ Scribed by Heike Heuer


Book ID
119194995
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
200 KB
Volume
21
Category
Article
ISSN
1521-690X

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Cellular thyroid hormone uptake and efflux are mediated by transmembrane transport proteins. One of these, monocarboxylate transporter 8 (MCT8) is mutated in Allan-Herndon-Dudley syndrome, a severe mental retardation associated with abnormal thyroid hormone constellations. Since mice deficient in Mc