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The importance of somatic mutations in the Vλ gene 2a2 in human monoclonal anti-DNA antibodies

✍ Scribed by Anisur Rahman; Joanna Haley; Emma Radway-Bright; Sylvia Nagl; Douglas G Low; David S Latchman; David A Isenberg


Book ID
115630828
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
456 KB
Volume
307
Category
Article
ISSN
0022-2836

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The CDKff2 gene, encoding the cyclin-dependent kinase inhibitor p16. is a tumour suppressor gene that maps to chromosome band 9p2 I -p22. The most common mechanism o f inactivation of this gene in human cancers is through homorygous deletion; however, in a smaller proportion of tumours and tumour ce