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The Importance of Pharmacokinetics in Determining the Relative Potency of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2,3,7,8-Tetrachlorodibenzofuran

โœ Scribed by Michael J. DeVito; Linda S. Birnbaum


Book ID
115608412
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
230 KB
Volume
24
Category
Article
ISSN
0272-0590

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Pharmacokinetics and biological activity
โœ Klaus Abraham; Ralf Krowke; Diether Neubert ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 967 KB

Concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rat liver and adipose tissue, and hepatic ethoxyresorufin O-deethylase (EROD) activity were studied subsequent to a single subcutaneous injection of TCDD. Two types of experiments were performed to study: (a) time-dependent changes foll