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The importance of mucosal immunity in defense against epithelial cancers

✍ Scribed by Véronique Revaz; Denise Nardelli-Haefliger

Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
119 KB
Volume
17
Category
Article
ISSN
0952-7915

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✦ Synopsis

Many cancers arise in epithelial mucosa. These mucosal surfaces are characterized by the induction of divergent immune responses, as they are both the main portal of entry for pathogens and a large niche of commensal bacteria and tolerized antigens. In addition, mucosa located in different anatomical sites harbor distinct typical features. Exploiting the different requirements for inducing an effective immune response at mucosal sites might help to define new immunotherapeutic approaches against epithelial cancers, at least in the case of differentiated tumors that have retained their mucosal characteristics.

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