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The importance of liposomes as models and tools in the understanding of photosensitization mechanisms

✍ Scribed by Maryse Hoebeke

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 919 KB
Volume: 28
Category: Article
ISSN: 1011-1344
DOI: 10.1016/1011-1344(95)07132-l

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✦ Synopsis

The various applications of liposomes in understanding photosensitization are described in this paper, with particular emphasis on the various kinds of information that these models allow to obtain in phototherapy. Liposomes are simple vesicles in which an aqueous phase is enclosed by a phospholipidic membrane. They are suitable models mimicking specific situations occurring m vivo and they allow study of the influence of physieochemieal, photobioiogieal and biochemical factors on the uptake of photosensitizers by tissues, their mechanisms of action and the subsequent photoinduced tumor necrosis. Moreover, solubilization )f the sensitizer into the bilayer seems to improve its tumoral selectivity and its photodynamic efficiency.

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