Evolutionary constraints in the mechanis
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C. M. Visser
📂
Article
📅
1980
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Springer
🌐
English
⚖ 721 KB
Analysis of the possible evolution of flavin catalysis in succinate dehydrogenase suggests as the ultimate state an active site that bears one or more acid functions and uses the enediol form of the substrate rather than the carbanion as a nucleophile. In the case of flavoenzyme catalyzed oxidation