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The Importance of a Family History of Breast Cancer in Predicting the Presence of a BRCA Mutation

✍ Scribed by William D. Foulkes; Jean-Sébastien Brunet; Ellen Warner; Pamela J. Goodwin; Wendy Meschino; Steven A. Narod; Paul E. Goss; Gordon Glendon


Book ID
119769996
Publisher
American Society of Human Genetics
Year
1999
Tongue
English
Weight
55 KB
Volume
65
Category
Article
ISSN
0002-9297

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## Abstract Three mutations in __BRCA1__ (5382insC, C61G and 4153delA) are common in Poland and account for the majority of mutations identified to date in Polish breast and breast–ovarian cancer families. It is not known, however, to what extent these 3 founder mutations account for all of the BRC