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The Importance of a Family History of Breast Cancer in Predicting the Presence of a BRCA Mutation

✍ Scribed by William D. Foulkes; Jean-Sébastien Brunet; Ellen Warner; Pamela J. Goodwin; Wendy Meschino; Steven A. Narod; Paul E. Goss; Gordon Glendon

Book ID: 119769996
Publisher: American Society of Human Genetics
Year: 1999
Tongue: English
Weight: 55 KB
Volume: 65
Category: Article
ISSN: 0002-9297
DOI: 10.1086/302675

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## Abstract Three mutations in __BRCA1__ (5382insC, C61G and 4153delA) are common in Poland and account for the majority of mutations identified to date in Polish breast and breast–ovarian cancer families. It is not known, however, to what extent these 3 founder mutations account for all of the BRC