The Implication of Electrocatalysis in MCR Strategy: Electrocatalytic Multicomponent Transformation of Cyclic 1,3-Diketones, Aldehydes and Malononitrile into Substituted 5,6,7,8-Tetrahydro-4H-Chromenes

✍ Scribed by Michail N. Elinson; Alexander S. Dorofeev; Sergey K. Feducovich; Sergey V. Gorbunov; Ruslan F. Nasybullin; Fedor M. Miloserdov; Gennady I. Nikishin

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 100 KB
• Volume: 2006
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200600544

✦ Synopsis

Abstract

The electrochemically induced catalytic multicomponent transformation of cyclic 1,3‐diketones, aldehydes and malononitrile in alcoholic solvents results in the formation of substituted 5,6,7,8‐tetrahydro‐4__H__‐chromenes in 85–95 % yields. The reaction is performed in an undivided cell in the presence of sodium bromide as an electrolyte. The application of this efficient electrocatalytic method to the formation of tetrahydro‐4__H__‐chromenes is beneficial for diversity‐oriented large‐scale processes. The novel concept of an electrocatalytic multicomponent reaction is also ecologically sound. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)