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The impact of α-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice

✍ Scribed by Cheol-Koo Lee; Thomas D Pugh; Roger G Klopp; Jode Edwards; David B Allison; Richard Weindruch; Tomas A Prolla


Book ID
113629096
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
325 KB
Volume
36
Category
Article
ISSN
0891-5849

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✍ Constance Schmelzer; Hiroshi Kubo; Masayuki Mori; Jinko Sawashita; Mitsuaki Kita 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB

Our present study reveals significant decelerating effects on senescence processes in middle-aged SAMP1 mice supplemented for 6 or 14 months with the reduced form (Q 10 H 2 , 500 mg/kg BW/ day) of coenzyme Q 10 (CoQ 10 ). To unravel molecular mechanisms of these CoQ 10 effects, a genome-wide transcr