The impact of vector-mediated neutrophil recruitment on cutaneous leishmaniasis

TNF-α mediates the induction of nitric o

TNF-α mediates the induction of nitric oxide synthase in macrophages but not in neutrophils in experimental cutaneous leishmaniasis

✍ Simone G. Fonseca; Pedro R. T. Romão; Florêncio Figueiredo; Ruth H. Morais; Herm 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 403 KB

Leishmania major infection in C57BL/6 mice is controlled by the activation of a Th1 response and nitric oxide (NO) production by macrophages. TNF-alpha is considered one of the most important cytokines involved in this response. In the present study, we investigated the expression of nitric oxide sy