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The impact of toxicity dose-response relationships on quantitative risk analysis results

✍ Scribed by Jeffrey S. Ferguson; Dennis C. Hendershot

Book ID
105358961
Publisher
American Institute of Chemical Engineers
Year
2000
Tongue
English
Weight
800 KB
Volume
19
Category
Article
ISSN
1066-8527

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✦ Synopsis

Abstract

The toxicity dose‐response relationship is a critical data requirement for a quantitative risk analysis of a chemical processing facility. This paper will review:

The use of toxicity dose‐response relationships in a quantitative risk analysis

The development of dose‐response relationships for use in a quantitative risk analysis from toxicity data

Examples of variation in published dose‐response relationships for some common chemicals

The impact of differences in dose‐response relationships on the results of a quantitative risk analysis

Finally, we propose the development of a standard protocol for development of toxicity dose‐response relationships for use in quantitative risk analysis, with emphasis on the benefits to the chemical industry of a standardized methodology.

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