𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease

✍ Scribed by Pablo Martinez-Martin; Carmen Rodriguez-Blazquez; Monica M. Kurtis; K. Ray Chaudhuri; on Behalf of the NMSS Validation Group

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
894 KB
Volume
26
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background:

Non‐motor symptoms are detrimental to health‐related quality of life (HRQoL) of Parkinson's disease patients. In this study, the Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients.

Methods:

In a multicenter, international, cross sectional study on 411 Parkinson's disease patients, the NMSS was applied along with clinical (Hoehn and Yahr staging and SCOPA‐Motor) and HRQoL measures (PDQ‐39, and EQ‐5D). Prevalence of non‐motor symptoms was determined also through the NMSS. The association of NMSS and SCOPA‐Motor with HRQoL measures and the differences in HRQoL scores between patients with and without non‐motor symptoms in each NMSS domain were estimated by non‐parametric statistics. Predictors of HRQoL were sought through multiple linear regression analyses.

Results:

Nocturia (68.4% of the sample), fatigue (65.9%), and dribbling saliva (56.7%), were the most frequent complaints. Total NMSS score: (1) showed a higher correlation coefficient (r~S~ = 0.70) with the PDQ‐39 Summary Index (SI) than SCOPA‐Motor (r~S~ = 0.58); (2) showed high‐moderate correlation (r~S~ = 0.60 − 0.38) with all PDQ‐39 domains; and (3) was the best predictor of HRQoL as measured by the PDQ‐39 SI. For each NMSS domain, patients with symptoms had significantly worse HRQoL scores than patients without symptoms.

Discussion:

To our knowledge, this is the first study to determine in a holistic manner the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. The results show that non‐motor symptoms have, as a whole, a greater impact on HRQoL than motor symptoms and non‐motor symptoms progression contributes importantly to HRQoL decline in patients with Parkinson's disease. © 2011 Movement Disorder Society

📜 SIMILAR VOLUMES

Nonmotor symptoms are independently asso
Nonmotor symptoms are independently associated with impaired health-related quality of life in Chinese patients with Parkinson's disease
✍ Huijuan Li; Meifen Zhang; Ling Chen; June Zhang; Zhong Pei; Ailing Hu; Qing Wang 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 83 KB

## Abstract We performed a cross‐sectional study of 82 Chinese patients with Parkinson's disease (PD) enrolled during an 18‐month period using a clinical interview to assess the prevalence of nonmotor symptoms (NMS), the association with disease severity and motor status, and the impact on patients

Impact of the motor complications of Par
Impact of the motor complications of Parkinson's disease on the quality of life
✍ Stéphane Chapuis; Lemlih Ouchchane; Olivier Metz; Laurent Gerbaud; Franck Durif 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 86 KB 👁 1 views

## Abstract The impact of motor complications of Parkinson's disease (PD), especially levodopa‐induced dyskinesias, on quality of life (QL) was studied in 143 patients with PD. All were evaluated on the Hoehn and Yahr (H&Y) scale, and the Motor part of the Unified Parkinson's Disease Rating Scale (

Impact of apathy on health-related quali
Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study
✍ Julián Benito-León; Esther Cubo; Carlos Coronell; on behalf of the ANIMO Study G 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 789 KB

## Abstract The impact of apathy on health‐related quality of life (HRQOL) in recently diagnosed Parkinson's disease (PD) has not been systematically investigated. The objective of this cross‐sectional survey (ANIMO study) was to examine the contribution of apathy to HRQOL in a Spanish sample of re

Coping processes and health-related qual
Coping processes and health-related quality of life in Parkinson's disease
✍ R. S. Bucks; K. E. Cruise; T. C. Skinner; A. M. Loftus; R. A. Barker; M. G. Thom 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 147 KB 👁 1 views

## Abstract ## Objective This study investigated the predictive value of various coping processes for the psychological and disease specific aspects of health‐related quality of life (HRQoL) in Parkinson's disease (PD). ## Method Cross‐sectional study of 85 participants with PD using the Ways of

Predictors and course of health-related
Predictors and course of health-related quality of life in Parkinson's disease
✍ Elin Bjelland Forsaa; Jan Petter Larsen; Tore Wentzel-Larsen; Karen Herlofson; G 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 84 KB 👁 1 views

## Abstract We investigated how health related quality of life (HRQL) changes over time in a population‐based cohort of patients with Parkinson's disease (PD), and which factors predict a lower level of HRQL in these patients. Of 227 patients with PD assessed at baseline and followed prospectively,

Quality of life in early Parkinson's dis
Quality of life in early Parkinson's disease: Impact of dyskinesias and motor fluctuations
✍ Connie Marras; Anthony Lang; Murray Krahn; George Tomlinson; Gary Naglie 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 80 KB 👁 1 views

## Abstract The impact of dyskinesias and motor fluctuations on quality of life (QOL) at various stages in the course of Parkinson's disease (PD) is not well understood. In 301 subjects with early PD enrolled in a clinical trial (CALM‐PD), we quantified the impact of motor complications on QOL and