✦ LIBER ✦

The impact of FISH on our understanding of testicular tumour development

✍ Scribed by Ensinger, Christian; Mikuz, Gregor

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 126 KB
Volume: 186
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199811)186:3<225::aid-path176>3.0.co;2-d

No coin nor oath required. For personal study only.

✦ Synopsis

The fusion of techniques of classical cytogenetics and molecular biology has led to the establishment of the fluorescence in situ hybridization (FISH) technique. This method, allowing detailed chromosomal investigations in metaphase spreads as well as in interphase nuclei, has enabled pathologists to detect molecular changes in precancerous lesions such as carcinoma in situ of the testis. In particular, its application to paraffin material has allowed the correlation of chromosomal aberrations with morphological and immunohistochemical characteristics. Thus, recurrent chromosomal aberrations found in invasive testicular tumours, such as the occurrence of an isochromosome i(12p), are already present in preinvasive stages, indicating an early event in carcinogenesis. Recent work, published in this issue, presents the diagnostic and prognostic impact of these investigations. 1998 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Stereology and its impact on our underst

Stereology and its impact on our understanding of human placental functional morphology

✍ Mayhew, Terry M.; Burton, Graham J. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 1 views

The new stereology permits the objective, quantitative description of morphology by efficient and design-based methods. Applications to placentas in normal and abnormal pregnancies have proved of great value for challenging earlier misconceptions and interpreting better the processes of growth, morp

The role of familial values in understan

The role of familial values in understanding the impact of social class on weight concern

✍ Ogden, Jane ;Thomas, Debra 📂 Article 📅 1999 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 115 KB 👁 1 views

Objective: To examine the role of social class on aspects of weight concern and to assess the possible impact of values on mediating this association. Method: Two hundred fifty-seven girls ranging in age from 13 to 16, from either a fee paying inner city independent girls school (higher class school

Recent developments in our understanding

Recent developments in our understanding of the plant cuticle as a barrier to the foliar uptake of pesticides†

✍ Kirkwood, Ralph C 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB 👁 1 views

The plant cuticle is a highly complex membrane which forms the outer surface of the aerial portion of plants. The nature of the plant cuticle is reviewed with particular regard to its action as a potential barrier to the penetration of pesticide molecules ; the role of the cuticular waxes is highlig

Inhibitory effects of parasitism by the

Inhibitory effects of parasitism by the gregarious endoparasitoid Cotesia congregata on host testicular development

✍ Darcy A. Reed; Marcia J. Loeb; Nancy E. Beckage 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 479 KB 👁 1 views

Acknowledgments: The authors heartily thank Ms. Frances Tan for overseeing the insect rearing, Ms. Celvida Hernandez for expert assistance with collection of wasp ovaries and venom glands, and Ms. Linda Bobbitt and Mr. Michael Capriotti for technical assistance with graphics and photography.

Impact of sanitary and phytosanitary sta

Impact of sanitary and phytosanitary standards on developing countries and the role of the SPS Agreement

✍ Spencer Henson; Rupert Loader 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 67 KB 👁 1 views

This article addresses the role and impact of the General Agreement on Tariffs and Trade (GATT) Sanitary and Phytosanitary (SPS) Agreement on prospects for export trade by developing countries. The SPS Agreement aims to facilitate discussion under the aegis of the World Trade Organization (WTP). It

The early development of visuo-spatial a

The early development of visuo-spatial attention and its impact on social looking

✍ Butcher, Phillipa R. ;Kalverboer, Alex F. 📂 Article 📅 1997 🏛 John Wiley and Sons ⚖ 139 KB 👁 1 views

Research with adult subjects has provided convincing evidence for the existence of a covert visual attention system with the function of modulating shifts in overt visual attention, or gaze. The covert visual attention system becomes functional during the first 6 months of life. However, little is k