The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
β Scribed by Matthew P. Goetz; Stacey K. Knox; Vera J. Suman; James M. Rae; Stephanie L. Safgren; Matthew M. Ames; Daniel W. Visscher; Carol Reynolds; Fergus J. Couch; Wilma L. Lingle; Richard M. Weinshilboum; Emily G. Barr Fritcher; Andrea M. Nibbe; Zeruesenay Desta; Anne Nguyen; David A. Flockhart; Edith A. Perez; James N. Ingle
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 239 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Objective The sum of the serum levels of risperidone (RIS) and 9-hydroxyrisperidone (9-OH-RIS), which is the active moiety serum level, could be important for estimating the clinical effects of RIS. However, there have been no consistent results reported about the relationship between cytochrome P45
## Abstract __Microsomal cytochrome P450 monooxygenases of groups 1β3 are mainly expressed in the liver and play a crucial role in phase 1 reactions of xenobiotic metabolism. The cDNAs encoding human CYP2D6 and human NADPHβP450 oxidoreductase (CPR) were transformed into the methylotrophic yeast__ P
## Abstract The polymorphic enzyme cytochrome P450 CYP2D6 is involved in the metabolism of many antidepressants, including nortriptyline and fluoxetine. Some 7%β10% Caucasians have inactivating mutations in both alleles of the __CYP2D6__ gene, and are referred to as poor metabolizers (PMs). Several