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The Impact of Costimulatory Molecule Gene Polymorphisms on Clinical Outcomes in Liver Transplantation

✍ Scribed by Brad A. Marder; Bernd Schröppel; Marvin Lin; Thomas Schiano; Rulan Parekh; Yaron Tomer; Barbara Murphy

Book ID
114423584
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
213 KB
Volume
3
Category
Article
ISSN
1600-6135

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Background: The cytotoxic T lymphocyte antigen 4 (CTLA-4) gene encodes for a membrane bound (mCTLA-4) and a soluble sCTLA-4 isoform, which are both involved in regulation of T cell function. The CTLA-4 ϩ49A/G single nucleotide polymorphism (SNP) influences expression of mCTLA-4; ϩ6230G/A SNP affects