The impact of contralateral mastectomy on mortality in BRCA1 and BRCA2 mutation carriers with breast cancer
β Scribed by Steven A. Narod
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 133 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Women with a mutation in __BRCA1__ or __BRCA2__ face a lifetime risk of breast cancer of βΌ80%, and following the first diagnosis the10βyear risk of contralateral breast cancer is βΌ30%. It has been shown that both tamoxifen and oophorectomy prevent contralateral breast cancer, but it is
## Abstract There is conflicting evidence as to whether individuals who are heterozygous for germβline __BRCA1__ or __BRCA2__ mutations have an altered phenotypic cellular response to irradiation. To investigate this, chromosome breakage and apoptotic response were measured after irradiation in per