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The impact of androgen deprivation on quality of life after radical prostatectomy for prostate carcinoma

✍ Scribed by Floyd J. Fowler Jr.; Mary McNaughton Collins; Elizabeth Walker Corkery; Diana B. Elliott; Michael J. Barry

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
194 KB
Volume
95
Category
Article
ISSN
0008-543X

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✦ Synopsis

Abstract

BACKGROUND

Androgen deprivation is commonly prescribed for men with a rising prostate specific antigen level after radical prostatectomy, despite scant evidence regarding its efficacy and side effects. In the current study, the authors compared measures of health‐related quality of life (HRQOL) in men who were treated with androgen deprivation after radical prostatectomy with those for men who underwent surgery but were not treated with androgen deprivation.

METHODS

Medicare Provider and Analysis and Review (MedPAR) files were used to identify men who had undergone radical prostatectomies between 1991–1992. Medicare Part B data then were used to select two samples: men who subsequently were androgen deprived and those who were not. In 1999, a mail survey was administered that addressed a range of disease‐related and treatment‐related issues, including HRQOL. Age‐adjusted comparisons of responses to seven multiitem measures of HRQOL were performed.

RESULTS

The overall response rate was 82%. On all seven HRQOL measures (impact of cancer and treatment, concern regarding body image, mental health, general health, activity, worries about cancer and dying, and energy), there were statistically significant decrements associated with androgen deprivation.

CONCLUSIONS

Patients and physicians must weigh the price patients pay with regard to HRQOL against the uncertain benefits of early androgen deprivation. Cancer 2002;95:287–95. © 2002 American Cancer Society.

DOI 10.1002/cncr.10656

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