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The immunosuppressant and hyperplasia-inducing drug cyclosporin A regulates the cell cycle and cyclin B1 gene expression in gingival fibroblasts in vitro

โœ Scribed by Mohamed H. Parkar; Farah Hussain; Ambika Wickramaratna; Irwin Olsen

Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
137 KB
Volume
317
Category
Article
ISSN
0302-766X

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Selective induction of cell cycle regula
Selective induction of cell cycle regulatory genes cdk1 (p34cdc2), cyclins a/b, and the tumor suppressor gene RB in transformed cells by okadaic acid
โœ Jinsong You; R. Curtis Bird ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 962 KB

Genes encoding cdkl (~34'~''), cyclin A, cyclin B, and the tumor suppressor gene Rb are fundamental regulators of cell cycle progression which associate as a complex with the transcription factor E2F. Expression of many of these proteins has previously been shown to be repressed by okadaic acid, a s