The immunoregulatory effects of NK cells: the role of TGF-β and implications for autoimmunity

✍ Scribed by David A. Horwitz; J.Dixon Gray; Kazuo Ohtsuka; Makoto Hirokawa; Tetsu Takahashi

• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 379 KB
• Volume: 18
• Category: Article
• ISSN: 0167-5699
• DOI: 10.1016/s0167-5699(97)01149-3

✦ Synopsis

GCD4* + CDEI' WCW4' + CDB' ' cells, including macrophagw and IymphwyteP, have the capacity b prodwe TGF-P, and virtually a,, cell hjpes express hiahaffinihr ,e&ive,y activates CDS-T rd,s ,a ~mliferate", and a"g",c",r the maturatio" of T tells ,mm naive LO activated or memos crw. The regulabry effects of TGF-,, on T-cell cyrokiae prcdtiio" is contnr versia,. hme gm"ps have rqxvtpd that TGF-6 fadlitates ,he conditioning of CD4* ce,,s to pmducr IL-2 and lFNq (Ref. 341. Mhen, however, "port that TGF-B has ,he oppasite e'fect and pmmotw h"mora, immuni(y by upregulating 1L-4, n-5 and IL-10 pmdvc ,ialP. The ultimate effrx, "f TGF-,3 is presumably *e,cml,"cd by ,he inferacting ce,,s and cytokincs in the immediate milieu. NOVEMBER Suppressive * cytokmes Active TGF-8 .-_ NK cell IMMUNOLOGY TODAY systems is IgA antibody production or nonresponsiveness. It is Thus, in addition to their c) totoxic activities as a first line of de-likely that NK ceils have an important role in promoting this negafense in combating infectious agents, NK cells may have an equally tive response by their ability to provide TGF-p. Without stimulation, NK cells in peripheral blood produce nanomolar amounts of this cytokine (see above). TGF-p has a mapr role in blocking important role in immune regulation, where they limit the response maternal-fetal immune responses in pregnancy and here also NK cells appear to be a ma@ source during the first trimesteP. NKcell-derived TGF-P, therefore, may be responsible for the infreto foreign antigens and prevent autoimmunity5'-55. Although a quency of detectable immune responses in organ systems that are subject to intense antigenic stimulation. TGF-P-dependent nonlytic inhibitory circuit has been the focus of attention in this article, antibndy production can also be downregu-